Chemical name: Sibutramine
Tablet count: 80 tablets
Each tablet contains: Sibutramine 10 mg
BTS-PRO - Sibutramine usually as sibutramide hydrochloride monohydrate, is an orally administred agent for the treatment of obesity it is a centrally-acting serotonin-norepinephrine reuplake inhibitor structurally related to amphetamines, althrough its mechanism of action is disctinct.
Sibutramine is well absorbed from the GI tract (77%) but undergoes considerable first-pass metabolism reducing its bioavailability. The drug itself reaches its peak plasma level after 1 hour and has also a half-life of 1 hour. Sibutramine is metabolized excreted in the urine.
Sibutramine is a neurotransmitier reuplake inhibitor that reduces the reuptake of serotonin (by 53%) norepinephrine (by 54%), and dopamine (by 16%), thereby increasing the levels of these substances ins synaptic clefts and helping enhance satlety; the serotonergic action, in particular, is thought to influence appetite. Older anorectic agents such as amphotamine and lenfluramine force the release of these neurotransmiters rather than affecting their reuplake.
Despite having a mechanism of action similar to tricyclic antidepressants, sibutramine has failed to demostrate antidepressant propieties in animal stiduies. It was approved by the U.S. Food and Drug Administration (FDA) in November 1997 for the treatment of obesity.